Negative regulation of transmission of nerve impulse

Across TCGA patient cohorts, RNA activity of the Negative regulation of transmission of nerve impulse pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ROCK2, ITGAL, and PTPN6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transmission of nerve impulse activity versus ROCK2 in COAD (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ROCK2 →	+0.145	+0.053	.004	.009	3	4
COAD	ITGAL →	-0.311	-0.071	.001	.001	3	4
COAD	PTPN6 →	-0.241	-0.082	<.001	<.001	3	4
HNSC	RPS6 →	+0.115	+0.469	.009	.003	3	4
GBM	SERBP1_S392 →	+0.454	+0.488	<.001	.002	3	4
UCEC	SMTN →	+0.944	+0.737	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051970 vs ROCK2 — COAD

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