"Positive regulation of synaptic transmission, glutamatergic"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of synaptic transmission, glutamatergic" pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM88, FAM110D, and ASPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of synaptic transmission, glutamatergic" activity versus TMEM88 in CCRCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TMEM88 →	+0.743	+0.708	<.001	<.001	3	5
CCRCC	FAM110D →	+0.881	+0.741	<.001	.001	3	5
BRCA	ASPA →	+0.559	+0.284	<.001	.001	3	5
CCRCC	MYCT1 →	+1.091	+0.734	<.001	<.001	3	5
CCRCC	PTPRB →	+0.712	+0.535	<.001	<.001	3	5
BRCA	CD36 →	+1.645	+0.388	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051968 vs TMEM88 — CCRCC

Explore this scatter interactively →