"Negative regulation of synaptic transmission, glutamatergic"

Across TCGA patient cohorts, RNA activity of the "Negative regulation of synaptic transmission, glutamatergic" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALD1_S73, DPYSL3, and VCL_S346, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of synaptic transmission, glutamatergic" activity versus CALD1_S73 in HNSC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CALD1_S73 →	-0.762	-0.145	<.001	<.001	3	8
HNSC	DPYSL3 →	-0.619	-0.142	<.001	.001	3	8
LSCC	VCL_S346 →	-0.481	-0.102	<.001	<.001	3	8
BRCA	VCL_S795 →	-0.556	-0.156	<.001	<.001	3	8
CCRCC	LMCD1 →	-0.473	-0.105	<.001	<.001	3	8
CCRCC	TAGLN →	-0.761	-0.093	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051967 vs CALD1_S73 — HNSC

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