"Negative regulation of synaptic transmission, glutamatergic"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of synaptic transmission, glutamatergic" pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, UBE2D3, and ARHGAP11B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP9 grouped by "Negative regulation of synaptic transmission, glutamatergic"-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ARHGAP9 →	-0.269	-0.282	<.001	<.001	3	4
STOMACH	UBE2D3 →	+0.515	+0.417	.001	.001	3	4
STOMACH	ARHGAP11B →	+0.101	+0.341	.009	.001	3	4
LIVER	NRBP1 →	-0.402	-0.343	.003	.002	3	4
BLOOD_Leukemia	ALKBH5 →	-0.226	-0.309	.002	.004	3	3
BLOOD_Lymphoma	JPH4 →	-0.210	-0.361	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP9 by "Negative regulation of synaptic transmission, glutamatergic" activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →