"Negative regulation of synaptic transmission, glutamatergic"

Across TCGA cell cohorts, RNA activity of the "Negative regulation of synaptic transmission, glutamatergic" pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATAD1, ADORA1, and PIMREG, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Negative regulation of synaptic transmission, glutamatergic" activity versus ATAD1 in SKIN (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ATAD1 →	+1.436	+0.526	.008	.007	3	12
OESOPHAGUS	ADORA1 →	-1.361	-0.289	.002	.003	3	9
BLOOD_Lymphoma	PIMREG →	-1.218	-0.215	.003	.009	3	8
OESOPHAGUS	GRIK2 →	-1.201	-0.402	.002	<.001	3	8
STOMACH	PPA1 →	+0.907	+0.531	.001	.009	3	8
PANCREAS	MARCHF2 →	-0.939	-0.258	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051967 vs ATAD1 — SKIN

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