"Regulation of synaptic transmission, glutamatergic"

Across TCGA patient cohorts, RNA activity of the "Regulation of synaptic transmission, glutamatergic" pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN16, PRNP, and GMFG, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, glutamatergic" activity versus ZSCAN16 in UVM (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ZSCAN16 →	-0.874	-0.048	<.001	<.001	3	15
ESCA	PRNP →	+0.916	+0.031	<.001	<.001	3	14
THYM	GMFG →	-1.362	-0.025	<.001	<.001	3	13
ESCA	NLGN2 →	+1.401	+0.033	<.001	<.001	3	13
THYM	TCP11L1 →	+0.624	+0.023	<.001	.004	1	15
THYM	LCK →	-1.547	-0.025	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051966 vs ZSCAN16 — UVM

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