"Regulation of synaptic transmission, glutamatergic"

Across TCGA patient cohorts, RNA activity of the "Regulation of synaptic transmission, glutamatergic" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EP400, RBBP6, and PPP1R18_S368, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, glutamatergic" activity versus EP400 in HNSC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EP400 →	-0.148	-0.032	.001	.005	3	6
GBM	RBBP6 →	-0.238	-0.068	<.001	<.001	3	6
OV	PPP1R18_S368 →	+0.733	+0.033	.001	<.001	3	5
HNSC	SF3B1 →	-0.147	-0.034	<.001	<.001	3	5
LSCC	SF3B3 →	-0.156	-0.028	.001	.001	3	5
GBM	SON →	-0.192	-0.054	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051966 vs EP400 — HNSC

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