"Regulation of synaptic transmission, glutamatergic"

Across TCGA cell cohorts, RNA activity of the "Regulation of synaptic transmission, glutamatergic" pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPNS1, PEX1, and EIPR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPNS1 grouped by "Regulation of synaptic transmission, glutamatergic"-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CAPNS1 →	-0.203	-1.097	<.001	<.001	3	5
BLOOD_Leukemia	PEX1 →	-0.430	-1.102	.002	.006	3	4
SOFT_TISSUE	EIPR1 →	-0.190	-1.140	.009	.003	2	5
CNS	CTDSPL →	-0.333	-1.155	.001	<.001	3	4
CNS	PPP1R3B →	-0.387	-0.935	<.001	.008	3	4
BLOOD_Leukemia	PTK2B →	-0.217	-0.815	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPNS1 by "Regulation of synaptic transmission, glutamatergic" activity — SKIN

Explore this box plot interactively →