"Regulation of synaptic transmission, glutamatergic"

Across TCGA cell cohorts, RNA activity of the "Regulation of synaptic transmission, glutamatergic" pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53INP2, GNB5, and ELOB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of synaptic transmission, glutamatergic" activity versus TP53INP2 in URINARY_TRACT (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TP53INP2 →	+1.307	+1.404	.009	.002	3	6
STOMACH	GNB5 →	+1.442	+1.248	.002	.001	3	5
BLOOD_Leukemia	ELOB →	-0.517	-0.884	.001	<.001	2	5
BLOOD_Leukemia	LYL1 →	+1.773	+0.739	.003	.004	3	4
OESOPHAGUS	SNRPA →	-0.583	-1.230	<.001	<.001	3	4
STOMACH	C20orf194 →	+2.143	+1.390	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051966 vs TP53INP2 — URINARY_TRACT

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