Positive regulation of synapse assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF2K, EARS2, and CYTIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synapse assembly activity versus EEF2K in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EEF2K →	+0.377	+0.430	.007	.009	3	5
BRCA	EARS2 →	+0.386	+0.376	.001	.004	3	4
GBM	CYTIP →	-0.903	-0.928	<.001	<.001	3	4
GBM	OTUD1 →	-0.439	-0.782	.003	<.001	3	4
HNSC	CCDC69 →	-0.830	-0.769	<.001	.004	3	4
HNSC	CASP10 →	-0.516	-0.710	.007	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051965 vs EEF2K — BRCA

Explore this scatter interactively →