Positive regulation of synapse assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LACTB, SERINC3, and NMT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LACTB grouped by Positive regulation of synapse assembly-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LACTB →	-1.691	-1.320	.001	.004	3	4
LUNG_NSCLC_LUSC	SERINC3 →	-0.719	-0.970	.009	.003	3	4
LUNG_NSCLC_LUSC	NMT2 →	-2.198	-1.258	.001	.006	3	4
LUNG_NSCLC_LUSC	ITGA5 →	-2.440	-0.940	.002	.005	3	4
LUNG_NSCLC_LUSC	APBB1 →	-2.204	-1.310	.008	.004	3	4
LUNG_NSCLC_LUSC	SLC35B4 →	-1.152	-0.950	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LACTB by Positive regulation of synapse assembly activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →