Negative regulation of synapse assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of synapse assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BACH1_S196, SFN, and TCIRG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of synapse assembly activity versus BACH1_S196 in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BACH1_S196 →	+0.333	+0.125	<.001	.001	3	6
UCEC	SFN →	+0.819	+0.123	.005	<.001	2	7
COAD	TCIRG1 →	+0.357	+0.057	.001	<.001	3	6
BRCA	S100A12 →	+0.871	+0.053	<.001	.004	3	5
PDAC	S100A8 →	+1.085	+0.120	.003	.006	3	5
BRCA	S100A9 →	+1.048	+0.076	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051964 vs BACH1_S196 — HNSC

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