Negative regulation of synapse assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAL3ST4, MMP2, and NLRP1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of synapse assembly activity versus GAL3ST4 in LUNG_NSCLC_LUAD (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GAL3ST4 →	-1.137	-1.597	.003	<.001	3	2
LUNG_NSCLC_LUAD	MMP2 →	-5.216	-1.597	.004	<.001	3	1
LUNG_NSCLC_LUAD	NLRP1 →	-2.643	-1.597	.005	<.001	3	1
LUNG_NSCLC_LUAD	TGFB2 →	-6.196	-1.597	<.001	<.001	3	1
LUNG_NSCLC_LUAD	CFH →	-2.957	-1.597	.003	<.001	3	1
LUNG_NSCLC_LUAD	ETV7 →	-1.339	-1.722	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051964 vs GAL3ST4 — LUNG_NSCLC_LUAD

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