Regulation of synapse assembly

Across TCGA cell cohorts, RNA activity of the Regulation of synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP6, EIF3E, and ASIC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synapse assembly activity versus TRIP6 in BREAST (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TRIP6 →	-1.915	-0.159	.007	.007	3	5
BLOOD_Myeloma	EIF3E →	-1.087	-0.198	.004	.005	3	4
OVARY	ASIC1 →	-1.666	-0.260	<.001	.001	3	4
LARGE_INTESTINE	AMPD2 →	-0.421	-0.142	.009	.005	3	4
LARGE_INTESTINE	PXDC1 →	+2.016	+0.206	.002	.005	3	4
OVARY	TMEM265 →	+2.068	+0.216	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051963 vs TRIP6 — BREAST

Explore this scatter interactively →