Negative regulation of nervous system development

Across TCGA cell cohorts, RNA activity of the Negative regulation of nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNB2, POLR1H, and IDS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCNB2 grouped by Negative regulation of nervous system development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCNB2 →	+0.838	+1.459	<.001	<.001	3	4
BLOOD_Leukemia	POLR1H →	+0.735	+1.380	<.001	<.001	3	4
BREAST	IDS →	-0.849	-0.695	.004	.002	3	4
CNS	MARK1 →	+1.723	+1.030	<.001	.001	3	4
CNS	CTBS →	-0.551	-0.668	.007	.004	3	4
CNS	AMIGO2 →	-1.812	-0.645	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCNB2 by Negative regulation of nervous system development activity — BLOOD_Leukemia

Explore this box plot interactively →