Negative regulation of nervous system development

Across TCGA cell cohorts, RNA activity of the Negative regulation of nervous system development pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APLP1, HNRNPC, and SLC9A9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APLP1 grouped by Negative regulation of nervous system development-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	APLP1 →	-0.360	-0.105	.008	.008	3	5
LUNG_SCLC	HNRNPC →	-0.282	-0.068	.002	.008	3	5
LARGE_INTESTINE	SLC9A9 →	+0.168	+0.078	.002	.002	3	5
BLOOD_Lymphoma	APLNR →	+0.386	+0.117	.002	.001	3	4
BONE	SLC2A14 →	-0.362	-0.113	<.001	<.001	3	4
BONE	MUSK →	-0.170	-0.094	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APLP1 by Negative regulation of nervous system development activity — BONE

Explore this box plot interactively →