Negative regulation of nervous system development

Across TCGA cell cohorts, RNA activity of the Negative regulation of nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, SLC15A3, and IRF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nervous system development activity versus RPL3 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPL3 →	-0.959	-0.417	.001	.001	3	8
SKIN	SLC15A3 →	+2.704	+0.323	<.001	<.001	3	8
BONE	IRF1 →	+2.167	+0.464	.002	.006	3	7
CNS	HLA-A →	+2.476	+0.296	.002	.005	3	7
STOMACH	NT5E →	+3.835	+0.456	.002	.008	2	8
CNS	XAF1 →	+2.466	+0.218	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051961 vs RPL3 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →