Positive regulation of amino acid transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF496, RPL24, and ACTA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amino acid transport activity versus ZNF496 in BRCA (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF496 →	-0.332	-0.474	.002	.001	3	6
LUAD	RPL24 →	-0.376	-0.694	<.001	<.001	3	5
GBM	ACTA2 →	-0.647	-0.532	.001	.001	3	5
PDAC	POGLUT2 →	-0.317	-0.603	.001	<.001	3	5
COAD	MRAS →	-0.829	-0.502	<.001	<.001	3	5
COAD	HTRA1 →	-0.818	-0.324	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051957 vs ZNF496 — BRCA

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