Regulation of amino acid transport

Across TCGA patient cohorts, RNA activity of the Regulation of amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPR, TIPIN, and GTF3C3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amino acid transport activity versus TPR in HNSC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TPR →	-0.478	-0.315	.008	.002	3	5
CCRCC	TIPIN →	-0.295	-0.215	.005	.003	3	5
PDAC	GTF3C3 →	-0.167	-0.506	.007	.007	3	5
UCEC	RNF216 →	-0.386	-0.535	.005	.001	3	5
COAD	NRBP1 →	-0.242	-0.291	.003	.007	3	5
PDAC	HPF1 →	-0.288	-0.675	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051955 vs TPR — HNSC

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