Regulation of amino acid transport

Across TCGA cell cohorts, RNA activity of the Regulation of amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NACA, HNRNPA1, and DTD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amino acid transport activity versus NACA in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NACA →	-0.875	-0.164	.001	<.001	3	6
URINARY_TRACT	HNRNPA1 →	-0.621	-0.395	.004	.005	3	5
LARGE_INTESTINE	DTD2 →	-0.701	-0.210	.006	.006	3	4
URINARY_TRACT	MRPS28 →	-1.035	-0.385	.001	.003	3	4
URINARY_TRACT	RPL7 →	-0.632	-0.287	.008	.002	3	4
URINARY_TRACT	CCT2 →	-0.800	-0.379	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051955 vs NACA — UPPER_AERODIGESTIVE_TRACT

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