Positive regulation of amine transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of amine transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSZ, LOXL2, and FLNB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTSZ grouped by Positive regulation of amine transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CTSZ →	-5.054	-1.778	<.001	<.001	3	6
BONE	LOXL2 →	-5.280	-1.488	<.001	.001	3	5
BONE	FLNB →	-2.392	-1.741	<.001	<.001	3	5
PANCREAS	CLDND2 →	-0.715	-0.922	.001	.003	3	5
LIVER	FAH →	-0.719	-1.239	.007	.006	3	5
LIVER	SC5D →	+0.946	+1.689	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTSZ by Positive regulation of amine transport activity — BONE

Explore this box plot interactively →