Positive regulation of amine transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of amine transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM21, SLC7A5, and TRIM29, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amine transport activity versus TIMM21 in LUNG_NSCLC_LUSC (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TIMM21 →	-1.382	-0.320	.007	.002	3	5
LUNG_NSCLC_LUAD	SLC7A5 →	+1.877	+0.229	<.001	<.001	3	5
LUNG_NSCLC_LUAD	TRIM29 →	+1.981	+0.189	.006	<.001	3	5
KIDNEY	CCT8 →	-0.907	-0.278	.008	.001	3	5
UPPER_AERODIGESTIVE_TRACT	NDUFS2 →	-0.795	-0.208	.005	.005	3	5
LUNG_NSCLC_LUAD	KHSRP →	-0.477	-0.186	.005	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051954 vs TIMM21 — LUNG_NSCLC_LUSC

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