Negative regulation of amine transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of amine transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE1A, PTRH2, and PUS7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amine transport activity versus PDE1A in GBM (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PDE1A →	+0.658	+0.584	.007	.009	3	5
PDAC	PTRH2 →	-0.232	-0.260	.003	.009	3	5
BRCA	PUS7 →	-0.620	-0.552	<.001	.002	3	5
BRCA	CKS1B →	-0.633	-0.449	.001	.007	3	5
LSCC	DCAF13 →	-0.347	-0.510	.001	.004	3	5
UCEC	PDSS1 →	-0.632	-0.884	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051953 vs PDE1A — GBM

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