Negative regulation of amine transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of amine transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNNT1, SERF2, and NR2C2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amine transport activity versus TNNT1 in LARGE_INTESTINE (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNNT1 →	-3.708	-0.296	<.001	<.001	3	2
LARGE_INTESTINE	SERF2 →	+0.593	+0.377	.009	.008	2	3
LARGE_INTESTINE	NR2C2 →	-0.689	-0.259	<.001	.006	3	2
LARGE_INTESTINE	ZNF696 →	-0.715	-0.249	<.001	.009	3	2
OESOPHAGUS	NBPF26 →	-1.423	-1.791	.005	.001	3	2
CNS	ADAMTS10 →	+2.941	+0.255	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051953 vs TNNT1 — LARGE_INTESTINE

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