Regulation of catecholamine uptake involved in synaptic transmission

pathway activity — cross-omics
GO:0051940Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of catecholamine uptake involved in synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN2, RSU1, and PARVA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCSEPTIN2 →-0.234-0.099<.001.00238
BRCARSU1 →-0.382-0.103<.001<.00137
BRCAPARVA →-0.443-0.112<.001<.00137
BRCAVCL →-0.386-0.120<.001<.00136
OVDMD →-0.362-0.108.001<.00136
BRCAKANK2 →-0.455-0.095.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration