Regulation of catecholamine uptake involved in synaptic transmission

pathway activity — cross-omics
GO:0051940Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of catecholamine uptake involved in synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3B, PTTG1, and FOLR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCRAB3B →+1.928+0.312<.001<.00135
LSCCPTTG1 →+0.579+0.153.001.00235
OVFOLR1 →-2.461-0.167<.001<.00134
LSCCCACNA1B →+1.151+0.188<.001<.00134
LSCCDOLPP1 →+0.523+0.215.001<.00134
GBMPPIAP35 →+0.240+0.195.008.00734
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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