Gamma-aminobutyric acid import

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid import pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRAPPC9, YWHAE, and HTATIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid import activity versus TRAPPC9 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRAPPC9 →	+0.204	+0.136	<.001	<.001	3	5
PDAC	YWHAE →	-0.091	-0.049	.002	.006	3	4
PDAC	HTATIP2 →	+0.293	+0.062	.006	.002	3	4
UCEC	LAMB1 →	-0.444	-0.156	.001	.002	3	4
UCEC	LAMC1 →	-0.615	-0.183	<.001	<.001	3	4
PDAC	NBEAL2 →	+0.197	+0.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051939 vs TRAPPC9 — GBM

Explore this scatter interactively →