Gamma-aminobutyric acid import

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid import pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A13, SLC6A12, and RTN4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid import activity versus SLC6A13 in CCRCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC6A13 →	+1.906	+0.718	.001	.004	3	2
CCRCC	SLC6A12 →	+1.344	+0.963	<.001	<.001	3	2
CCRCC	RTN4 →	+0.259	+0.529	.003	.001	3	2
GBM	CGREF1 →	+0.943	+0.978	<.001	<.001	3	2
GBM	GPR61 →	+0.550	+0.777	<.001	.001	3	2
CCRCC	GVQW3 →	+0.327	+0.521	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051939 vs SLC6A13 — CCRCC

Explore this scatter interactively →