Gamma-aminobutyric acid import

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid import pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB44, LRRC14B, and OTULIN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB44 grouped by Gamma-aminobutyric acid import-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZBTB44 →	+0.646	+1.373	.001	.006	3	5
LIVER	LRRC14B →	+0.105	+2.251	.002	.009	3	4
STOMACH	OTULIN →	-0.580	-1.295	.004	<.001	3	4
STOMACH	PCYT1A →	-1.112	-1.534	.007	.002	3	4
SKIN	OPA3 →	-0.354	-0.856	.008	.007	3	3
SKIN	PTS →	-0.746	-1.361	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB44 by Gamma-aminobutyric acid import activity — SOFT_TISSUE

Explore this box plot interactively →