Gamma-aminobutyric acid import

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid import pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR5A1, SEC23B, and LYL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR5A1 grouped by Gamma-aminobutyric acid import-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR5A1 →	-0.287	-0.449	.002	.008	3	4
OVARY	SEC23B →	+0.215	+1.437	.006	.001	3	3
OVARY	LYL1 →	+0.221	+1.403	<.001	<.001	3	3
OVARY	ZNF530 →	-0.310	-1.208	.003	.003	3	3
KIDNEY	PDAP1 →	-0.187	-0.269	.004	.007	3	3
CNS	SLC41A3 →	+0.335	+0.224	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR5A1 by Gamma-aminobutyric acid import activity — KIDNEY

Explore this box plot interactively →