L-glutamate import

Across TCGA patient cohorts, RNA activity of the L-glutamate import pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2K6, SMAP2_S235, and TDP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate import activity versus MAP2K6 in COAD (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MAP2K6 →	-0.394	-0.031	<.001	.001	3	5
HNSC	SMAP2_S235 →	-0.348	-0.042	<.001	.002	3	4
GBM	TDP1 →	-0.258	-0.042	.004	.002	3	4
GBM	TMA16 →	-0.343	-0.049	.002	<.001	3	4
LUAD	UBASH3A_S384 →	-0.717	-0.041	.001	.001	3	3
LUAD	GATAD2A_S100 →	-0.426	-0.038	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051938 vs MAP2K6 — COAD

Explore this scatter interactively →