L-glutamate import

Across TCGA patient cohorts, RNA activity of the L-glutamate import pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2D3-AS1, SC5D, and CD79B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate import activity versus UBE2D3-AS1 in OV (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UBE2D3-AS1 →	+0.345	+0.174	.003	.006	3	4
BRCA	SC5D →	+0.523	+0.419	.006	.003	3	4
BRCA	CD79B →	-0.721	-0.602	.005	.003	3	4
BRCA	ARHGAP42P2 →	+0.206	+0.377	.001	.008	3	3
BRCA	TMPRSS13 →	-0.810	-0.494	.002	.008	3	3
GBM	RPS27 →	-0.388	-0.320	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051938 vs UBE2D3-AS1 — OV

Explore this scatter interactively →