Catecholamine uptake involved in synaptic transmission

pathway activity — cross-omics
GO:0051934Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Catecholamine uptake involved in synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ELL, SPTB_S1226, and SRRM2_S1542, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVELL →-0.338-0.141<.001.00334
BRCASPTB_S1226 →+1.224+0.103<.001<.00133
OVSRRM2_S1542 →-0.829-0.216.003.00124
CCRCCDIDO1_S154 →-0.327-0.107<.001<.00133
COADNONO_T418 →+0.740+0.290.001.00333
CCRCCSNCA →+0.770+0.147<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration