Amino acid neurotransmitter reuptake

Across TCGA cell cohorts, RNA activity of the Amino acid neurotransmitter reuptake pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC23A3, ZWINT, and G0S2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC23A3 grouped by Amino acid neurotransmitter reuptake-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC23A3 →	+0.174	+0.162	<.001	.003	1	6
LIVER	ZWINT →	+0.345	+1.275	<.001	.001	3	3
LIVER	G0S2 →	+0.486	+1.873	.001	<.001	3	3
LIVER	COG2 →	-0.287	-1.152	<.001	.004	3	3
LIVER	SEZ6L2 →	+0.265	+1.665	<.001	<.001	3	3
LIVER	GATA2 →	+0.231	+1.381	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC23A3 by Amino acid neurotransmitter reuptake activity — CNS

Explore this box plot interactively →