"Synaptic transmission, GABAergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, GABAergic" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POF1B, DNAJB5, and LINC01800, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, GABAergic" activity versus POF1B in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POF1B →	-1.096	-0.886	<.001	<.001	3	4
COAD	DNAJB5 →	-0.380	-0.214	.006	.003	3	3
UCEC	LINC01800 →	+0.231	+0.898	.002	.004	3	3
GBM	NAMPT →	-1.054	-1.199	.002	<.001	3	3
GBM	CALN1 →	+1.522	+1.262	<.001	<.001	3	3
GBM	MCF2 →	+0.586	+1.094	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051932 vs POF1B — BRCA

Explore this scatter interactively →