"Synaptic transmission, GABAergic"

Across TCGA cell cohorts, RNA activity of the "Synaptic transmission, GABAergic" pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYURF, DNLZ, and MGST1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PYURF grouped by "Synaptic transmission, GABAergic"-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PYURF →	-0.539	-1.059	.002	.001	3	5
STOMACH	DNLZ →	-1.027	-0.798	.003	.004	3	4
SOFT_TISSUE	MGST1 →	-3.659	-1.028	.003	.001	3	4
BLOOD_Leukemia	RNF34 →	-0.577	-1.152	.001	<.001	3	3
PANCREAS	DNM1 →	+2.017	+0.952	.005	.001	3	3
PANCREAS	LTBP2 →	-1.488	-0.646	.001	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PYURF by "Synaptic transmission, GABAergic" activity — SOFT_TISSUE

Explore this box plot interactively →