Negative regulation of calcium ion transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B3, KCTD12, and SNRPD2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transport activity versus SF3B3 in OV (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SF3B3 →	-0.194	-0.034	.003	.001	2	8
LSCC	KCTD12 →	+0.332	+0.057	<.001	<.001	3	7
OV	SNRPD2 →	-0.265	-0.025	.005	.008	2	7
LSCC	U2SURP →	-0.256	-0.057	<.001	<.001	3	6
LSCC	SART1 →	-0.172	-0.045	<.001	<.001	3	6
LSCC	CMPK2 →	+0.542	+0.068	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051926 vs SF3B3 — OV

Explore this scatter interactively →