Negative regulation of calcium ion transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHSRP, EIF3A, and PTBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transport activity versus KHSRP in PANCREAS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KHSRP →	+1.015	+0.338	.001	.005	3	6
PANCREAS	EIF3A →	+0.599	+0.213	.004	.004	3	6
OVARY	PTBP1 →	+0.938	+0.327	.001	.001	3	5
SKIN	DEPP1 →	-2.034	-0.215	<.001	.002	3	5
LIVER	FEM1A →	+0.955	+0.412	<.001	.006	3	5
LIVER	RAVER1 →	+1.271	+0.359	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051926 vs KHSRP — PANCREAS

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