Regulation of calcium ion transport

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCCHC7, PSMB6, and GRK6P1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZCCHC7 grouped by Regulation of calcium ion transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZCCHC7 →	-0.258	-0.087	.002	.009	2	6
STOMACH	PSMB6 →	-0.377	-0.082	.001	<.001	3	5
LUNG_NSCLC_LUAD	GRK6P1 →	+0.169	+0.054	<.001	.001	3	5
BLOOD_Myeloma	C1QTNF3 →	-0.267	-0.070	.006	.007	3	4
LUNG_SCLC	SERTAD4 →	+0.228	+0.083	.001	.009	3	4
BONE	KRT14 →	-0.243	-0.089	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZCCHC7 by Regulation of calcium ion transport activity — OVARY

Explore this box plot interactively →