Regulation of calcium ion transport

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDS, ZNFX1, and TMEM158, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion transport activity versus IDS in LIVER (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IDS →	+2.211	+0.316	<.001	.001	3	6
LIVER	ZNFX1 →	+1.195	+0.425	<.001	<.001	3	6
LIVER	TMEM158 →	+3.288	+0.340	<.001	<.001	3	6
BONE	SERPINB8 →	+3.052	+0.380	<.001	.001	3	6
LIVER	UBE2A →	+1.115	+0.275	.001	.009	3	6
SOFT_TISSUE	HPRT1 →	+1.100	+0.274	.006	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051924 vs IDS — LIVER

Explore this scatter interactively →