Sulfation

Across TCGA patient cohorts, RNA activity of the Sulfation pathway is significantly associated with the RNA expression of multiple genes, with the PCPG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UST, SULT1A1, and SULT1A2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfation activity versus UST in PCPG (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PCPG	UST →	+1.212	+0.027	<.001	.003	1	19
ACC	SULT1A1 →	+1.496	+0.075	.001	<.001	3	14
CHOL	SULT1A2 →	+2.007	+0.121	<.001	<.001	3	12
ESCA	NFATC2 →	-1.398	-0.075	<.001	<.001	3	12
LAML	GLCCI1 →	-0.986	-0.054	<.001	<.001	3	12
THYM	ZNF101 →	-0.803	-0.041	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051923 vs UST — PCPG

Explore this scatter interactively →