Sulfation

Across TCGA patient cohorts, RNA activity of the Sulfation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH4A1, NCKAP1, and SULT1C2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfation activity versus ALDH4A1 in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ALDH4A1 →	+0.298	+0.104	.003	<.001	3	5
HNSC	NCKAP1 →	+0.188	+0.081	<.001	<.001	3	5
LUAD	SULT1C2 →	+1.175	+0.085	<.001	<.001	3	5
LUAD	PLXNB2 →	+0.244	+0.082	<.001	<.001	3	5
PDAC	SYTL2 →	+0.458	+0.082	<.001	<.001	3	5
LUAD	UTP15 →	-0.240	-0.055	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051923 vs ALDH4A1 — HNSC

Explore this scatter interactively →