Sulfation

Across TCGA patient cohorts, RNA activity of the Sulfation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR378G, MTHFD1, and RPS12P26, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfation activity versus MIR378G in OV (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MIR378G →	+0.524	+0.980	.002	.006	3	3
GBM	MTHFD1 →	-0.377	-0.516	<.001	.003	3	3
BRCA	RPS12P26 →	+0.952	+0.752	<.001	<.001	3	3
BRCA	HSP90B2P →	+1.145	+0.584	<.001	.003	3	3
COAD	SCML2 →	-0.555	-0.622	.002	<.001	3	3
COAD	PHF8 →	-0.505	-0.563	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051923 vs MIR378G — OV

Explore this scatter interactively →