Sulfation

Across TCGA cell cohorts, RNA activity of the Sulfation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC170, TMEM64, and DUSP16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC170 grouped by Sulfation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CCDC170 →	-1.400	-1.060	.004	.004	3	4
BLOOD_Leukemia	TMEM64 →	+1.137	+1.061	.008	.002	3	4
LIVER	DUSP16 →	-1.230	-1.419	.001	<.001	3	4
SKIN	SGK2 →	-0.323	-0.928	.001	<.001	3	4
BREAST	AKAP7 →	+0.848	+0.772	.004	.002	3	3
BREAST	ESR1 →	-2.405	-0.869	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC170 by Sulfation activity — STOMACH

Explore this box plot interactively →