Negative regulation of fibrinolysis

Across TCGA patient cohorts, RNA activity of the Negative regulation of fibrinolysis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPRIP, IGFBP7, and CDC42EP3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fibrinolysis activity versus ITPRIP in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ITPRIP →	+0.465	+0.166	.001	.001	3	7
LSCC	IGFBP7 →	+0.784	+0.223	<.001	<.001	3	7
BRCA	CDC42EP3 →	+0.611	+0.084	.002	.005	3	7
LSCC	SERPINE1 →	+1.360	+0.217	<.001	<.001	3	6
GBM	COL6A2 →	+1.325	+0.210	.002	<.001	3	6
COAD	ITGA5 →	+0.933	+0.122	.002	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051918 vs ITPRIP — LSCC

Explore this scatter interactively →