Negative regulation of fibrinolysis

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibrinolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAT, SERPINE1, and RAB33A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLAT grouped by Negative regulation of fibrinolysis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PLAT →	-0.370	-1.201	<.001	<.001	3	6
LIVER	SERPINE1 →	-0.253	-1.610	<.001	.001	3	4
OESOPHAGUS	RAB33A →	-0.154	-1.208	.008	.001	3	4
SOFT_TISSUE	FGF21 →	-0.198	-1.315	.003	<.001	3	4
SOFT_TISSUE	PACSIN1 →	-0.169	-1.298	.006	<.001	3	4
SOFT_TISSUE	MASP2 →	-0.323	-1.259	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLAT by Negative regulation of fibrinolysis activity — CNS

Explore this box plot interactively →