Negative regulation of fibrinolysis

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibrinolysis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHST15, UBE2H, and PDIA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHST15 grouped by Negative regulation of fibrinolysis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CHST15 →	+1.211	+1.309	.001	<.001	3	4
URINARY_TRACT	UBE2H →	+0.970	+1.522	<.001	<.001	3	4
LIVER	PDIA5 →	-1.435	-1.404	<.001	.006	3	3
LIVER	HYAL2 →	-0.592	-1.090	.004	.002	3	3
LUNG_SCLC	DGCR8 →	+1.181	+1.144	<.001	.001	3	3
OVARY	TNFSF13B →	+0.312	+1.209	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHST15 by Negative regulation of fibrinolysis activity — OESOPHAGUS

Explore this box plot interactively →