Negative regulation of fibrinolysis

Across TCGA cell cohorts, RNA activity of the Negative regulation of fibrinolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMY2B, PYCARD, and CBX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AMY2B grouped by Negative regulation of fibrinolysis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AMY2B →	-0.183	-0.303	.006	.002	3	4
LUNG_NSCLC_LUAD	PYCARD →	-0.129	-1.017	.008	.008	3	3
LUNG_NSCLC_LUAD	CBX1 →	-0.133	-1.009	<.001	.005	3	3
BLOOD_Lymphoma	SHISA2 →	-0.425	-0.357	.003	.002	3	3
SKIN	PRKCG →	+0.190	+1.214	.005	.007	3	3
SKIN	ISCU →	+0.526	+1.534	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMY2B by Negative regulation of fibrinolysis activity — LUNG_SCLC

Explore this box plot interactively →