Regulation of fibrinolysis

Across TCGA patient cohorts, RNA activity of the Regulation of fibrinolysis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL8A1, ITPRIP, and VEGFC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fibrinolysis activity versus COL8A1 in OV (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COL8A1 →	+1.392	+0.172	<.001	<.001	3	8
COAD	ITPRIP →	+0.811	+0.258	<.001	<.001	3	8
OV	VEGFC →	+1.055	+0.215	<.001	.001	3	8
OV	PCOLCE →	+1.330	+0.244	<.001	<.001	3	8
OV	SERPINE1 →	+1.469	+0.190	<.001	<.001	3	8
COAD	SPARC →	+1.412	+0.322	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051917 vs COL8A1 — OV

Explore this scatter interactively →