Regulation of fibrinolysis

Across TCGA cell cohorts, RNA activity of the Regulation of fibrinolysis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD13B, LIG4, and C15orf62, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKRD13B grouped by Regulation of fibrinolysis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ANKRD13B →	+1.073	+0.903	<.001	<.001	3	4
BLOOD_Myeloma	LIG4 →	+1.552	+1.963	.004	<.001	3	4
OVARY	C15orf62 →	+0.596	+0.604	.009	.003	3	3
SOFT_TISSUE	JAGN1 →	+0.528	+0.288	.002	<.001	3	3
SKIN	GUSB →	-0.618	-1.016	.002	<.001	3	3
SKIN	EWSR1 →	-0.263	-1.170	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKRD13B by Regulation of fibrinolysis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →